A Study Of Car T-Cell Therapy And Its Effects On Handwriting And Coordination
Posted Date: Mar 10, 2025
- Investigator: Luca Marsili
- Specialties: Cancer, Movement Disorders, Neurology
- Type of Study: Observational/Survey
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a frequent complication of chimeric antigen receptor (CAR) T-cell therapy. This is a significant cause of morbidity. Prolonged hospitalization is required to monitor for ICANS. Handwriting changes are well-described in this condition and are often the first sign of impending neurotoxicity. This study will evaluate the ability of machine learning technology to detect subtle differences between those affected and unaffected by ICANS. This will be combined with a detailed phenomenological analysis of tremor, coordination, praxis, and other neurocognitive measures.
Criteria:
This Study Will Enroll Individuals Admitted To The Uc Blood Cancer Healing Center For Car T-Cell Therapy For Cancer Treatment.
Keywords:
Car T-Cell Therapy, Icans, Tremor
For More Information:
Luca Marsili, Md
(513) 218-6787
marsilla@ucmail.uc.edu