Cancer Related Cognitive Impairment (Crci) And Its Relationship To Specific Types Of Changes In Thinking And Other Medical Conditions
Posted Date: Apr 18, 2024
- Investigator: Rhonna Shatz
- Specialties: Breast Cancer, Cancer, Cardiovascular Disease, Head and Neck Cancer, Leukemia, Lung Cancer, Lymphoma, Memory Disorders, Neurology, Oncology, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer, Vascular
- Type of Study: Observational/Survey
In parallel with increasing numbers of cancer survivors, the incidence and impact of Cancer-Related Cognitive Impairment (CRCI) is expanding. • CRCI, most commonly consisting of executive dysfunction, presents anytime from diagnosis to years after remission1,which may indicate the impact of other comorbidities or risk factors. • CRCI may be a facet of the cancer itself, or toxic treatments such as chemotherapy and radiation, which trigger a pro-inflammatory state1. • Sleep Disruptions (SDs) from obstructive sleep apnea (OSA) and/or poor sleep quality causes executive dysfunction in the general population and may contribute to CRCI3. • SDs impede progression to sleep stages associated with enhanced glymphatic circulation and clearance of toxic proteins and inflammatory by-products, leading to ventriculomegaly (see Figure 1). • The Evan’s Index (EI), the ratio of the maximal width of the frontal horns to the maximum inner skull diameter, is a measure of ventricular volume, with a ratio >.3 indicating enlarged ventricles (ventriculomegaly). • Using data collected from 135 patients in the Cancer Cognitive Registry at UCGNI, this study investigated the incidence and type of SD in CRCI, the association of SD with executive dysfunction, and evidence of altered glymphatic circulation in SD
Criteria:
Diagnosis Of Cancer And Any Change In Thinking At Diagnosis, During Treatment, Or Anytime After Treatment
Keywords:
Crci (Cancer Related Cognitive Impairment, Chemobrain, Sleep Disorders
For More Information:
Rhonna S Shatz
2485057993
shatzra@ucmail.uc.edu