An Informatics Approach To Study The Associations Between Glp-1 Receptor Agonist Medications And Endoscopy And Anesthesia Outcomes
Posted Date: May 7, 2024
- Investigator: Inuk Zandvakili
- Specialties:
- Type of Study: Observational/Survey
Glucagon-like peptide-1 receptor agonists (GLP1RA) are associated with delayed gastric emptying, which has raised concerns regarding the risk of retained gastric contents during upper endoscopy and associated adverse anesthesia events such as pulmonary aspiration among GLP1RA treated patients. Moreover, delayed gastric emptying may negatively affect bowel preparation among GLP1RA treated patients resulting in inadequate bowel preparation for colonoscopy. We aim to assess for associations between GLP1RA exposure and retained gastric contents on upper endoscopy when controlling for age, sex, BMI, ICD10 codes for diabetes mellitus or gastroparesis, insulin or opiate use and hemoglobin A1c. We will additionally aim to assess for any associations between GLP1RA exposure and pulmonary aspiration during sedation for endoscopy. Lastly, we will assess for associations between GLP1RA exposure and inadequate bowel preparation as determined by increased rates of cancelled, aborted and incomplete colonoscopy, or by standardized language used to signify inadequate bowel preparation. To do so, we propose to analyze all outpatient endoscopies at UC Health and additional sites and abstract pre-procedural endoscopy and anesthesia notes, basic demographics, medications, ICD10 codes, procedural anesthesia record, recent labs and the associated endoscopy report(s). Text data will be analyzed through the use of natural language processing (NLP) algorithms and organized into structured data for statistical analysis.
Criteria:
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Keywords:
Glp-1 Receptor Agonists, Endoscopy
For More Information:
Inuk Zandvakili
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zandvaik@mail.uc.edu