Clinical Study

The Glycemia Reduction Approaches In Diabetes: A Comparative Effectiveness Study

Posted Date: Feb 7, 2018

  • Investigator: Robert Cohen
  • Specialties:
  • Type of Study: Drug

The GRADE study is a research study for people with type 2 diabetes. This research study will compare the effectiveness of four different medications that are used to treat type 2 diabetes. Each of the 4 medications will be used together with metformin. Metformin is the medication used most often to treat type 2 diabetes. Each medication combination used in the GRADE study has been approved by the U.S. Food and Drug Administration (FDA) and is commonly used to treat type 2 diabetes in adults. However, no study has ever compared these combinations “head-to-head”. Therefore, which combination treatment is best for adults with type 2 diabetes is not known. The GRADE study will compare how well the different medication combinations control blood sugar levels. We will also look at other benefits or side effects of each medication combination. Information from the GRADE study will help to determine the best treatment for type 2 diabetes.


You Are Being Asked To Take Part In This Research Study Because You Have Been Diagnosed With Type 2 Diabetes Mellitus. This Research Study Will Compare The Effectiveness Of Four Different Medications That Are Used To Treat Type 2 Diabetes.


Diabetes, Dr. Robert Cohen, Grade, Kathy Burton, Va Medical Center

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Angela Bauer