Evaluating The Mechanical And Histological Properties Of Deep Vein Thrombi In Vivo For Diagnostic Clinical Benefit.
Posted Date: Oct 14, 2024
- Investigator: Wisam Beauti
- Specialties: Emergency Medicine, Vascular
- Type of Study: Observational/Survey
There are 300 to 600 thousand cases of venous thromboembolism nationally every year costing with an estimated 2 to 10 billion dollars annually. With the advancement of medicine, more risk factors for venous thromboembolism are being identified. Analyzing and understanding the components of thrombi in situ are crucial in the first steps to determining the best treatment modality for VTE. We aim to identify specific components of vascular thrombi through assessing thrombus stiffness with ultrasound elastography and histological features. This has the potential to aid surgical treatment planning for mechanical thrombectomy versus catheter directed thrombolytic. Wisam Beauti, MD will consent eligible participants and collect elastography data on these patients. Histology on DVTs removed via thrombectomy will be analyzed. Statistical analysis will be performed using GraphPad Prism 9. The mean and standard deviation for shear wave speed and stiffness using Young’s modulus will be determined. These characteristics will be analyzed to assessed regarding their correlation to each other. Pearman’s nonparametric correlation coefficient will be used to assess correlations. A p value = 0.05 will be used to indicate statistical significance.
Criteria:
Null
Keywords:
Venous Thromboembolism, Deep Vein Thrombi, Elastography
For More Information:
Wisam Beauti
601-447-3873
beautiwm@ucmail.uc.edu