Building Capacity To Disseminate Findings Of Pcor/Cer Of Youth With Bipolar Spectrum Disorders (Bsd)
Posted Date: May 2, 2024
- Investigator: Melissa Delbello
- Specialties: Bipolar Disorder, Psychiatry/Psychology
- Type of Study: Observational/Survey
Background: Second-generation antipsychotic (SGAs) medications effectively manage symptoms of bipolar spectrum disorders (BSD) in youth, but SGA-related weight gain and metabolic side effects carry substantial risks. Our data suggest that these youth are willing to start interventions to minimize weight gain at SGA initiation. However, clinicians and caregivers are unlikely to intervene until youth have voiced concern about weight gain. Clinicians and other stakeholders also report a lack of knowledge regarding available solutions to SGA-related side effects. MOBILITY, a PCORI-funded CER study compares metformin plus a healthy lifestyle (LIFE) to LIFE alone among youth with BSD. Key outcomes include weight gain, metabolic alterations, and mood stability. Other PCORI-funded studies compare SGAs to other mood stabilizing medications, and report effective weight-mitigation strategies, and provide patient-centered feedback on the use of adult versus child guidelines for lipid testing and treatment. Proposed Solution to the Problem: To fill the gap in awareness of effective weight management strategies for youth with BSD, project leads from the University of Cincinnati and Depression and Bipolar Support Alliance, will build capacity to disseminate this evidence by convening a steering committee and focus groups of stakeholders who will meet online to determine what data from PCORI/CER studies relevant to youth with BSD will best support decision-making, and how this information should be disseminated to patients, caregivers and other stakeholders, so that we create a fast path from evidence to action by transferring knowledge about evidence-based management of SGA-related side effects to representative stakeholders. Objectives: The primary aims of this project are to build capacity to 1) understand what aspects of MOBILITY and other related-PCOR/CER study findings are most salient to stakeholders and 2) effectively and rapidly disseminate these findings so that youth with BSD experience improved outcomes. Activities: We will reach our objectives through bi-weekly Steering Committee meetings to identify key priorities and themes important to stakeholders, review qualitative and quantitative findings from focus groups, design targeted messaging and dissemination pathways for each stakeholder group and evaluate the progress of our efforts. Projected Outcomes and Outputs: Short-term outcomes during the project period include enhanced capacity for targeted dissemination of PCOR/CER findings to our stakeholder organizations, targeted messaging for each stakeholder and end user group and tailored communication strategies. Medium-term outcomes (0-2 years post-project period) include increased reach, widespread adoption of SGA side effect mitigation strategies. Long-term outcomes (3+ years post-project period) include improved physical and mental health of youth with BSD. Deliverables include a qualitative analysis of patient-, caregiver-, and clinician-reported key barriers and facilitators to dissemination, stakeholder-informed evidence-based recommendations to address BSD treatment/side effects, quantitative analyses of stakeholder engagement and increased knowledge and acceptability, and a resource detailing learnings on most acceptable dissemination strategies. Patient and Stakeholder Engagement Plan: We will engage the following stakeholders: youth living with BSD, their caregivers and prescribers, and representatives of health systems, community mental health agencies, professional organizations, and payors. They will meet regularly, as part of the Steering Committee and focus groups, to identify relevant PCOR evidence and provide feedback on best mechanisms to reach end users. Project Collaborators: • University of Cincinnati/Cincinnati Children’s Hospital Medical Center • Depression and Bipolar Support Alliance • American Academy of Child and Adolescent Psychiatry • CareSource
Criteria:
Youth With Bipolar Spectrum Disorders Who Have Taken An Sga, Caregivers And Clinicians Of Youth With Bipolar Spectrum Disorders Who Have Taken/Prescribed An Sga
Keywords:
Patient-Centered
For More Information:
Dr. Christina Kelin
NULL
kleinci@uc.edu