Clinical Study

Platelet-Oriented Inhibition In New Tia And Minor Ischemic Stroke (Point) Trial

Posted Date: Feb 8, 2018

  • Investigator: Kyle Walsh
  • Co-Investigator: Kyle Walsh
  • Specialties: Emergency Medicine, Stroke
  • Type of Study: Drug

The purpose of this research study is to determine the safety and effectiveness of the combination of low-dose aspirin and a medication called clopidogrel (also known by the brand name Plavix®) in reducing the risk of stroke, heart attacks and other complications in patients who have just had a transient ischemic attack (TIA). Patients who have had a TIA or minor stroke have a higher risk of developing a major stroke. Recognizing and treating TIAs or minor strokes can reduce your risk of a major stroke. Lowdose aspirin has been shown to be effective in preventing strokes and heart attacks in patients who have had a TIA or minor stroke. Clopidogrel is another medication that is used to prevent strokes and heart attacks in patients at risk for these problems. Clopidogrel is a type of medication called an antiplatelet drug, and it works by helping to keep platelets (small blood cells needed for normal blood clotting) in the blood from sticking together and forming harmful blood clots. This helps your blood flow more easily, and provides more protection against a future heart attack or stroke. Clopidogrel is approved for the prevention of a second stroke or TIA or minor stroke, and is taken once per day. Aspirin has also been shown to be effective in helping to prevent a second stroke and/or TIA and is approved in doses ranging from 50 to 325 mg per day. Several studies that tested the combination of clopidrogrel and aspirin have shown that taking these two medications together might protect patients even more from major stroke and heart attack after a TIA or minor stroke, in comparison to taking aspirin alone, these studies were small and the risk of bleeding was increased. The POINT research study has been designed to answer this question of whether the combination of aspirin and clopidogrel reduces the risk of stroke, heart attacks and other complications compared to aspirin alone in patients like you. This study is sponsored by the National Institutes of Health (NIH) and the National Institute of Neurological Disorders and Stroke (NINDS).

Criteria:

You Are Being Asked To Take Part In This Research Study Because You Are 18 Years Of Age Or Older And Because You Have Just Had A Tia Or Minor Stroke. A Tia Or Minor Stroke Is A Condition That Produces Stroke-Like Symptoms Like Sudden Weakness On One Side Of The Body Or Trouble Speaking. With A Tia, The Symptoms Are Temporary And In A Minor Stroke The Symptoms Mentioned Above Do Not Totally Go Away.

Keywords:

Emergency Medicine, Stroke, Null, Null, Null

For More Information:

Irene Ewing
(513) 558-3450
ewingi@ucmail.uc.edu

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