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  • 27 Feb 17

A Genetic Variant Can Predispose South Asians to Hypertrophic Cardiomyopathy

A genetic variant of myosin binding protein C, cardiac (MYBPC3), can predispose South Asians to hypertrophic cardiomyopathy (HCM), but early screening could lower its incidence. Sakthivel Sadayappan, PhD, MBA, professor, division of cardiovascular health and disease and director of the heart branch of Heart, Lung and Vascular Institute, University of Cincinnati Medical Center (UC Medical

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  • 02 Dec 14

Advancing the Standard of Care: Fibrinolytic Therapy Facilitated Transradial Percutaneous Coronary Intervention Effective Treatment for Acute STEMI

In the hands of experienced operators and high-volume transradial catheterization centers, transradial coronary angiography and intervention offer improved patient comfort, decreased access-site complications, and lower costs without compromising procedural success or long-term outcomes.

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  • 28 Oct 16

AlterG Treadmill May Transform Stress Testing for Cardiac Patients

The Division of Cardiovascular Health and Disease of the University of Cincinnati (UC) Medical Center is the first in the United States to study the AlterG ® Anti-Gravity Treadmill Pro 2001 to diagnose cardiovascular diseases and conditions. Myron Gerson, MD, emeritus professor of medicine, UC Medical Center, and Patrick Daly, MD, who recently completed his cardiology

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  • 11 May 15

An Aortic Center with Aggressive Aortic Rupture/Trauma Protocol: The Minutes That Can Save a Life

Endovascular repair of ruptured aortic aneurysms or aortic trauma repair has become the standard of care in recent years, overtaking the traditional open approach.

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  • 09 Sep 15

Are PCSK9 Inhibitors Potentially Appropriate for Patients With Mixed Hyperlipidemia and High Cardiovascular Risk, Despite Statins?

PCSK9 inhibitors are a new class of drugs, not yet FDA-approved, that have been shown to dramatically lower LDL cholesterol levels. Three clinicians discuss their potential. Video includes comments by Dylan Steen, MD, Department of Internal Medicine, Division of Cardiovascular Health and Disease, and UC Health cardiologist. View the video.  

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  • 14 Dec 15

Awareness, Referral, and Multidisciplinary Approach Key to Positive Outcomes in Cardiac Rehabilitation

A recent study of over 2,000 patients clearly demonstrated that patient participation in cardiac rehabilitation (CR) after percutaneous coronary intervention (PCI) was associated with a significant reduction in mortality rates.1 A large national survey, however, estimated that only an average of 28% of eligible patients were receiving CR.2 This underutilization is due to many factors,

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  • 22 Jan 15

BPA Exposure Affects Heart Health of Males and Females Differently in Mice

Heart function and blood pressure in mice exposed to bisphenol A (BPA) from birth though young adulthood are affected differently in males and females, with females at greater risk of damage from stress, a study from a University of Cincinnati (UC) researcher has found.

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  • 11 May 15

Cardio-oncology Program Launches Multi-Pronged Approach to Understanding, Treating, and Preventing Cardiotoxicity in Cancer Patients

The University of Cincinnati Medical Center is preparing to formally launch a Cardio-oncology Program, in response to substantial unmet needs to mitigate risk of acute and delayed cardiomyopathy resulting from cancer treatment.

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  • 09 Sep 15

Clinical Commentary on CIRCUS Trial Results

Dr. Richard Becker, Chief of the Division of Cardiovascular Health and Disease; and Director, and Physician-in-Chief, of the University of Cincinnati Heart, Lung and Vascular Institute, commented on phase II results of the CIRCUS trial while recently attending the European Society of Cardiology Congress. View the video.

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  • 02 Dec 14

Common BPA Substitute, BPS, Disrupts Heart Rhythms in Females

A University of Cincinnati researcher has found that Bisphenol S (BPS) in consumer products may have similar toxic effects on the heart as previously reported for Bisphenol A (BPA).

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  • 28 Oct 16

Developments in Arrhythmia Treatment: Reduced Procedure Time, Planning for Telemedicine

The Arrhythmia Center at the University of Cincinnati (UC) Medical Center, undergoing significant upgrades, is unique in its nationally and internationally recognized electrophysiology group which encompasses strong clinical performance, education and research. Alexandru Costea, MD, professor of medicine, director of the Center for Electrophysiology, Rhythm Disorders and Electro-mechanical Interventions, is leading this multi-faceted cardiac program.

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  • 05 Jun 15

Dr. Becker Comments on Pegasus Trial

After a presentation at the American College of Cardiology conference, Richard C. Becker, MD, American Heart Association spokesperson, discusses findings from the Pegasus Trial, also known as TIMI 54. Dr. Becker is the Mable Stonehill Endowed Chair, Professor of Medicine, University of Cincinnati College of Medicine, and Chief, Division of Cardiovascular Health and Disease at

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  • 11 May 15

Early ECMO Referral for Better Patient Prognosis

Used for decades as a tool in the treatment arsenal for cardiogenic shock, extracorporeal membrane oxygenation (ECMO) is being taken to a whole new level in about 100 shock programs in the United States, where unprecedented survival rates are beginning to be achieved.

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  • 20 May 16

ECMO Is a Bridge to Transplantation for A 35-Year-Old Man with Chest Pain

A 35-year-old male presented to a Dayton area hospital with two days of chest pain. He was taken to the cath lab where a left heart catheterization revealed 100% proximal occlusion and 100% left circumflex occlusion. He developed pulseless electrical activity (PEA) arrest, underwent cardiopulmonary support/advanced cardiac life support with return of spontaneous circulation within

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  • 21 Feb 17

EKOS Offers Great Benefits for High-Risk Pulmonary Embolism Patients

The EkoSonic Pulmonary Embolism (EKOS®) System is “so effective, even for the most complex cases, that it’s hard not to use it for all patients with pulmonary embolism [PE],” says Timothy Smith, MD. Dr. Smith, an interventional cardiologist, is director of the cardiovascular ICU and assistant professor of medicine at the University of Cincinnati Medical

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  • 20 May 16

Excellent Outcomes with New Minimally Invasive Heart Surgeries

The growth of transcatheter aortic valve replacements (TAVRs) and MitraClips has been “revolutionary,” says Satya Shreenivas, MD, assistant professor and director of the structural heart disease program at the University of Cincinnati Heart, Lung and Vascular Institute. The Institute’s focus is implanting heart valves nonsurgically by transcatheter aortic valve replacement as well as nonsurgical repair

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  • 27 Feb 17

Facial Muscle Cells May Help Repair Damage from Cardiovascular Disease

Researchers at the University of Cincinnati Medical Center (UC Medical Center) are investigating the use of facial muscle-derived progenitor cells – masseter muscle cells – to regenerate cardiomyocytes damaged by cardiovascular disease. Current therapies, such as medications, bypass surgery and donor hearts do not repair or replace cardiomyocytes and come with additional risks such as

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  • 01 Dec 14

Introducing Scholarvision: Physician to Physician Discussions on the Latest Innovations in Cardiovascular Medicine

University of Cincinnati Heart, Lung & Vascular Institute has introduced a video series known as Scholarvision. Researchers from the Institute and cardiology fellows discuss innovation, medical breakthroughs and the latest technology and treatment options related to cardiovascular medicine.

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  • 28 Oct 16

Investigation of a Novel Mediator of Cardiac Hypertrophy Funded by $1.7 Million Grant

Determining how the protein human antigen R (HuR) is activated, its function after activation, and possible association with cardiac hypertrophy are the goals of a study funded by a $1.7 million National Institute of Health (NIH) five-year grant recently awarded to Michael Tranter, PhD, and principal investigator for the study. Initial findings show that the

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  • 02 Dec 14

Kranias Receives Research Achievement Award

Evangelia (Litsa) Kranias, PhD, Hanna Professor and director of cardiovascular biology in the University of Cincinnati Department of Pharmacology and Cell Biophysics, was honored at the annual meeting of the International Society for Heart Research (ISHR) North American Section.

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  • 14 Dec 15

Landmark Trial to Examine Cardiovascular Treatment in HIV Patients

Over the course of their careers, many clinicians have seen HIV/AIDS progress from extremely high short-term mortality to chronic, long-term disease management. As HIV patients are living longer with antiretroviral therapy, it is becoming clear that the virus increases risk of cardiovascular conditions.1 The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) study will

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  • 20 May 16

Mission: Lifeline® – A Proactive System of Care to Improve Cardiac Outcomes

The American Heart Association (AHA) developed Mission: Lifeline® to transform cardiac outcomes for patients with both STEMI (ST-elevation myocardial infarction) and NSTE-ACS (non-ST-elevation acute coronary syndrome) by connecting healthcare providers, emergency medical services (EMS) personnel, and community residents.1 University of Cincinnati (UC) Medical Center has participated in Mission: Lifeline® since 2007. In the Spring of 2014, with

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  • 20 May 16

Monthly Clinic Provides Additional Prenatal Care for Women with Adult Congenital Heart Disease, Recovers Patients “Lost to Follow-Up”

Although more adults than children are living with congenital heart disease (CHD) because of advances in treatment and technology, this good news has a potential downside. Adults with CHD will experience complications as they age, yet only 39% continue to see a cardiologist, and most are “lost to follow-up.”1 For women in the latter category,

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  • 17 Dec 15

New Program Assesses Cardiovascular Risk In Utero, Cardiologist Nominated as FDA Commissioner

Dear Colleagues, At the University of Cincinnati Heart, Lung and Vascular Institute, we continue to grow in the areas of cardiovascular research and care by taking our findings and other key insights from the field and translating them into real treatments to help our patients each day. In this issue of Cardiovascular Insights, we highlight

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  • 24 Jun 15

New Surgeons and Scientists at the University of Cincinnati to Help Advance Cardiovascular Field

The University of Cincinnati has bolstered its Heart, Lung and Vascular Institute in recent months by hiring heart surgeons and scientists to fill seven new positions. Meet the new physicians.

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  • 09 Sep 15

OPTIDUAL Study Results

Dr. Richard Becker, Chief of the Division of Cardiovascular Health and Disease; and Director, and Physician-in-Chief, of the University of Cincinnati Heart, Lung and Vascular Institute, discusses the supportive results from the OPTIDUAL study and his approach to patients who have had stents implanted. View the video.

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  • 11 May 15

Optimal Management of Patients Surviving an Out of Hospital Cardiac Arrest

Patients who suffer cardiac arrests outside of hospitals generally die. Mortality is 90%, according to 2013 data reported by the American Heart Association (AHA).

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  • 10 Aug 15

Rb-82 PET/CT Facilitates Higher Diagnostic Accuracy in CAD

Early and accurate diagnosis of coronary artery disease (CAD) has never been more important, and University of Cincinnati Medical Center enhanced its own diagnostic capability by adding cardiac positron emission tomography (PET) with CT attenuation correction using rubidium-82 (Rb-82) in December 2014. The medical center has been using cardiac PET with a nitrogen-13 ammonia as

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  • 11 Dec 15

Recent Findings from a French General Practice Population Highlight Statin Underutilization in Patients with Severely Elevated Cardiovascular Risk

  Although the most current European Society of Cardiology guidelines recommend that patients at very high cardiovascular risk maintain a low-density lipoprotein cholesterol (LDL-C) of <70 mg/dL (<1.8 mmol/L), a recent study demonstrated that most patients from a French population do not meet this goal.1 One of the main causes is the chronic and widespread

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  • 19 Jun 15

Repurposing Drugs for Heart Failure Patients

Saad Ahmad, MD, cardiology fellow at the University of Cincinnati Heart, Lung and Vascular Institute, interviews Jack Rubinstein, MD, assistant professor in the UC College of Medicine, about his research that involves repurposing drugs for heart failure patients originally made for other conditions. Findings in his lab have accelerated the move from bench to bedside.

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  • 10 Aug 15

Research Focus in New Vascular Medicine Training Program

The University of Cincinnati Heart, Lung, and Vascular Institute (HLVI) will soon initiate a three-year Mentored Research Career Development Program in vascular medicine. The goal of this initiative is to establish a comprehensive training program that will emphasize high-quality clinical and translational research in the vascular sciences, and prepare participants to serve as mentors for

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  • 01 Sep 15

Scholarvision Episode 10

Dr. Becker interviews patient Mrs. Judy Kleinmann.

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  • 06 Jan 16

Scholarvision Episode 11 – Adult Congenital Heart Disease

  A discussion about adult congenital heart disease with Dr. Becker, Dr. Veldtman and Dr. Brown.

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  • 02 Jul 15

Scholarvision Episode 4

Richard Becker, MD, Director and Physician-in-Chief of the University of Cincinnati Heart, Lung and Vascular Institute, interviews Markus Gustche, MD, PhD, Assistant Professor in the UC College of Medicine, and Director of the Interstitial Lung Disease Program.

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  • 03 Aug 15

Scholarvision Episode 5

Richard Becker, MD, chief of the Division of Cardiovascular Health and Disease and director, and physician-in-chief of the University of Cincinnati Heart, Lung and Vascular Institute and Michael Ritt Jaff, DO, professor of medicine at Harvard Medical School and chair of the Massachusetts General Institute for Heart, Vascular and Stroke Care discuss vascular medicine career

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  • 03 Aug 15

Scholarvision Episode 6

This ScholarVision features Richard Becker, MD, chief of the Division of Cardiovascular Health and Disease and director, and physician-in-chief of the University of Cincinnati Heart, Lung and Vascular Institute; Joseph Broderick, MD, director of the University of Cincinnati Neuroscience Institute; and William Barrett, MD, director of the University of Cincinnati Cancer Institute. They discuss groundbreaking

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  • 01 Sep 15

Scholarvision Episode 7

Richard Becker, MD and his guests discuss heart transplant.

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  • 01 Sep 15

Scholarvision Episode 8, Part 1

Interview with Josep Brugada, MD, PhD Arrhythmia Unit, Hospital Clinic de Barcelona University of Barcelona, Spain

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  • 01 Sep 15

Scholarvision Episode 8, Part 2

Interview with Josep Brugada, MD, PhD Arrhythmia Unit, Hospital Clinic de Barcelona University of Barcelona, Spain Also featuring: Alexandru Costeau, MD Professor of Clinical Medicine University of Cincinnati Division of Cardiovascular Health and Disease

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  • 01 Sep 15

Scholarvision Episode 9

Interview with: Imran Arif, MD Professor of Clinical Medicine Division of Cardiovascular Health and Disease University of Cincinnati Satya S. Shreenivas, MD Assistant Professor of Clinical Medicine Division of Cardiovascular Health and Disease University of CIncinnati

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  • 09 Sep 15

Special Video Feature: Cardiovascular Insights

Dr. Richard Becker, Chief of the Division of Cardiovascular Health and Disease; and Director, and Physician-in-Chief, of the University of Cincinnati Heart, Lung and Vascular Institute is joined by Dr. David Feldman, Director of Advanced Myocardial and Circulatory and Director of Clinical Services of the Heart, Lung and Vascular Institute. In this video, they discuss

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  • 12 Aug 15

Transcatheter Aortic Valve Replacement (TAVR) Program

An unusually large patient cohort and state-of-the-art medical facilities have expedited rapid growth of the Transcatheter Aortic Valve Replacement (TAVR) Program at the University of Cincinnati Medical Center. As with many other cardiac diseases, such as coronary blockages and arrhythmias, valvular heart disease is now increasingly being treated in a minimally-invasive manner. This is especially important

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  • 20 May 16

Treating Cardiogenic Shock: A Multidisciplinary Team Approach Achieves Better Outcomes

University of Cincinnati (UC) Medical Center has instituted a team approach for the treatment of acute cardiogenic shock, setting it apart from most medical centers and providing a critical advantage for such acutely ill patients. “With our growing STEMI volume, the team identified the need to provide early intervention for the patient in acute cardiogenic

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  • 10 Aug 15

Ultrasound-Mediated Thrombolysis May Offer Promise

The standard of care paradigm has shifted in the treatment of ischemic stroke. At present, the only thrombolytic therapy approved by the U.S. Food and Drug Administration is recombinant tissue-type plasminogen activator (rt-PA), and this treatment is only administered to a small percentage of patients due to safety concerns and temporal limitations.1 Sonothrombolysis, or ultrasound-mediated

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  • 01 Dec 14

University of Cincinnati Researchers Identify Genetic Variant Linked to Heart Malfunction

University of Cincinnati researchers Evangelia Kranias, PhD, Jack Rubinstein, MD, and Hong-Sheng Wang, PhD, are among the co-authors of a study recently published in the Journal of the American Heart Association identifying a genetic variant in a cardiac protein that can be linked to heart rhythm malfunction and sudden cardiac death in dilated cardiomyopathy patients.

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  • 23 Oct 15

Webinar Series

Join UC Health for this monthly 1-hour webinar series for researchers and clinicians in cardiology, pulmonary and vascular medicine. View details and register today.

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  • 22 Jul 15

With $2.4M Grant, Researchers to Collaborate in Study of Heart Disease

After receiving a five-year, $2.4 million grant from the National Institute of Environmental Health Sciences (NIEHS), two University of Cincinnati researchers will collaborate on an investigation of gene-environment interactions during embryonic development and their consequences in adult heart disease. Alvaro Puga, PhD, of the Department of Environmental Health, and Jack Rubinstein, MD, of the Department

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  • 27 Feb 17

Working to Change the Leading Cause of Death Throughout the World

Every year, approximately 10 million people worldwide, including 600,000 Americans, suffer from venous thromboembolism (VTE),1 and at least one in 12 middle-aged American adults will develop VTE in their remaining lifetime,2 says Richard C. Becker, MD. These statistics are part of the impetus for a national awareness effort—World Thrombosis Day (WTD), which is designed to

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