RAMPART Trial Shows Auto-Injectors Faster, More Effective than IV Lines in Stopping Prolonged Seizures

Doctors conduct surgery

As part of the first national, randomized clinical trial to study two methods of drug delivery for seizing patients, researchers have shown that using an auto-injector, similar to an EpiPen, to deliver anticonvulsant medication stops prolonged seizures more quickly and effectively than drug delivery through an IV line.

The research, which will be published in the Feb. 16 edition of the New England Journal of Medicine, was conducted as part of the Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART), which included University of Cincinnati (UC) researchers and local paramedics as part of a nationwide effort studying status epilepticus, or prolonged seizure lasting more than five minutes.

Nationwide, RAMPART involved more than 79 hospitals, 33 emergency medical services agencies, more than 4,000 paramedics and 893 patients, ranging in age from several months old to age 103. The study was conducted through the Neurological Emergencies Treatment Trials (NETT) network and sponsored by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS), which formed NETT to link 17 major research hospitals to conduct clinical trials on acute conditions of the brain.

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